Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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Endometrial papillary syncytial change: Goodreads is the world’s largest site for readers with over 50 million reviews. It is emphasised that in the absence of the other morphological features of endometritis described earlier, an exhaustive search for plasma cells is not justified.

Most users should sign in with their email address. Hormones have varying effects emdometrial the endometrium and it is essential that the clinician supplies details lf the pathologist regarding any hormone treatment. Mixed epithelial and mesenchymal tumours. Visit our Beautiful Books page and find lovely books for kids, photography lovers and more.

As the effects of tamoxifen on the endometrium are believed to be due to oestrogenic activity, it is expected that most endometrial cancers should be endometrioid in type, as these neoplasms are hormone receptor positive. The residual atrophic glands are negative. Description Derived from the authors’ long-running course presented at the International Academy of Pathology, this second edition, now with color illustrations, continues the tradition of its predecessor as being the concise and complete diagnostic guide to the endometrial biopsy.

In complex hyperplasia, there is an increase in the gland to stroma ratio with glandular crowding. Mod Pathol 18 — In the distinction between an endometrioid and a serous carcinoma, immunohistochemical analysis may be of value. Int J Gynecol Pathol 23 — Occasional stromal plasma cells may be identified in an otherwise normal endometrium, and in these circumstances a diagnosis of endometritis should not be made.


Mixed endometrioid and serous carcinomas are not uncommon.

Endometrial stromal cells may have a plasmacytoid appearance with eccentric endometiral, and the pathologist should be certain that classic plasma cells are present.

With a thickened endometrium, a focal lesion or a strong clinical suspicion of major pathology, however, a scant specimen may be an indication of the need for repeat biopsy. Most epidemiological studies, however, suggest that tamoxifen is associated with an increased risk of developing endometrial cancer, which is two to three times that in patients with breast cancer who are not taking tamoxifen.

When a biopsy is carried out for abnormal uterine bleeding, the pathologist should always consider the possibility of a polyp. Mod Pathol 12 — Such information is not always provided. It is imperative that an endometrial cancer is both typed and graded, if appropriate, on an endometrial biopsy the term endometrial adenocarcinoma does not suffice, as endometrial adenocarcinomas may be of several different morphological subtypes.

As referred to previously, serous carcinoma and its presumed precursor lesion EIC also variously termed endometrial carcinoma in situ or surface serous carcinoma have a marked propensity to arise in or to be associated with otherwise benign endometrial polyps.

My approach to the interpretation of endometrial biopsies and curettings

Am J Surg Pathol 28 — A major proportion of the workload in many histopathology laboratories is accounted for by endometrial biopsies, either curettage specimens or outpatient biopsy specimens. Crushed endometrial glands and stroma may be extremely cellular and can cause concern.

Adenofibroma and adenosarcoma Adenofibroma, with a benign stromal component, and adenosarcoma, with a malignant one, are xiagnosis of the mixed epithelial and mesenchymal mixed Mullerian tumours of the uterus. Endometrial proliferative activity may occur with uterine prolapse and in endometrial polyps in postmenopausal women. A major problem is the distinction between simple endometrial hyperplasia and disordered proliferative endometrium, a term widely used, although the histological features are not well characterised.


My approach to the interpretation of endometrial biopsies and curettings

This article is also available for rental through DeepDyve. A biopsirs of simple hyperplasia should not be made in the case of an endometrial polyp, as a glandular architecture reminiscent of simple hyperplasia is a normal feature within a polyp.

In evaluating an endometrial biopsy specimen, an adequate clinical history is important, including the age of the endometriao and the reason for the biopsy. Antibodies against B and T lymphoid cells may also be of value. The morphological features of a cyclical and atrophic endometrium will not be detailed, but a few salient points are mentioned in the following sentences.

Endometrial carcinoma Issues relevant only to the diagnosis of endometrial carcinoma on biopsy specimens will be considered. Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles. It is useful to have a checklist of benign lesions other than those listed earlier, including granulomas, placental site nodules and the various forms of epithelial and stromal metaplasias.

In many cases of postmenopausal bleeding, the patient is not actually postmenopausal but rather is perimenopausal, with a prolonged interval between periods.