Carcinoma Mucoepidermoide de Glândulas. Salivares Menores. Mucoepidermoid Carcinoma of Minor Salivary Glands. Paulo Tinoco*, José Carlos Oliveira. Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica. Article (PDF Available) in Revista cubana de estomatología 49( 1). Pages CARTA CIENTÍFICO-CLÍNICA. DOI: / Carcinoma mucoepidermoide de labio. Mucoepidermoid Carcinoma of the Lip.
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Mucoepidermoid carcinoma of the salivary glands in Brazil: The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood. This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Mucoepidermkide effects of age, gender, anatomic localization, tumor size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated. Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test. A total of mucoepidwrmoide cases were analyzed over a period of 18 years; males were Surgical resection was performed in all patients.
The follow-up period in this study ranged from 6 muxoepidermoide months. The 5 and year overall survival rates were both Disease-free survival rates were Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis mucoepidermmoide useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival. There is a wide variation in these malignant neoplasms over different geographic areas and ethnic groups.
Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. The mucoepidermoid carcinoma generally shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing. The medical and surgical records of all cases were reviewed for clinicopathological factors, such as age, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.
MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas. Two oral pathologists reviewed all cases to histopathologically classify these tumors according to the protocol published by Brandwein and others 10which classifies tumors into low Grade Iintermediate Grade II or high Grade III grades.
Complete resection was defined as a histological report of negative margins of more than 10 mm. The DFS was calculated as the time interval between the date of first treatment and the date of local disease recurrence or last information for censored observations when the patient was known to be disease-free. The OS was defined as the interval between the beginning of the treatment and the date of death or last information for censored observations.
Data concerning survival recurrence and metastasis were evaluated. The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates.
The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively. The follow-up period in mucoepiderjoide study ranged from 6 to months median 65 monthsand the 5 and year OS rates were both The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively.
There were no statistically significant differences for any analyzed variable affecting OS curves. Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site. Tumors were stratified into three groups: In the present study, was set out to examine MEC behavior and csrcinoma outcomes to provide additional information on potential factors that could significantly affect the prognosis of these tumors.
Mucoeppidermoide were 16 cases of MEC diagnosed over an year period at our institution, which is similar to results reported by Triantafillidou and others 14 who found 16 cases over a year interval.
The broad age range observed in our series supports that reported in literature.
The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion. Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes.
Even though low-grade tumors did not develop metastases and high-grade tumors showed lower DFS rates after five years, no significant difference was found for the grading system or any of the evaluated prognostic factors. In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS.
Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports. There is a growing consensus that an aggressive surgical approach with adjuvant radiotherapy must always be considered for more advanced cases that present with a high histological grade, positive margins and cervical involvement.
Published works usually lose relevant survival information through time. Although this current investigation was limited by a relatively small sample size, there was a long follow-up period in which we could verify and confirm the influence of some prognostic factors.
Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples.
Through a long follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs.
Pattern of parotid gland tumors on Crete, Greece: Mucoepidermoid tumors of the salivary glands. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma.
Mucoepidermoid carcinoma of the salivary glands: Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. Mucoepidermoid carcinoma of the major salivary glands: Histopathologic grading of salivary gland neoplasms. Ann Otol Rhinol Laryngol. Mucoepidermoid carcinoma of intraoral salivary glands.
Evaluation and application of grading criteria in cases. Am J Surg Pathol. Seifert G, Sobin LH. Histological classification of salivary gland tumours.
International histological classification of tumours. Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Mucoepidermoid carcinoma of minor salivary glands: Mucoepidermoid carcinoma of the head and neck: Mucoepiedrmoide J Clin Oncol.
Carcinoma mucoepidermoide – Wikipedia
Intraoral mucoepidermoid carcinoma of salivary glands. Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. Otolaryngol Head Neck Surg. Carcinoma of the parotid and submandibular glands a study of survival in patients. University of Sao Paulo, Brazil.